(1,1'-Biphenyl)-2-carboxaldehyde → 2,6-Diamino-4-(biphenyl-2-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

HRID 328223

반응식

HRID 328223 반응식
[C:1]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:2]([CH:7]=O)=[CH:3][CH:4]=[CH:5][CH:6]=1.[CH2:15]([O:17][C:18](=[O:23])[CH2:19][C:20](=[NH:22])[NH2:21])[CH3:16]>C(O)C>[CH2:15]([O:17][C:18]([C:19]1[CH:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:19]([C:18]([O:17][CH2:15][CH3:16])=[O:23])=[C:20]([NH2:21])[NH:22][C:20]=1[NH2:21])=[O:23])[CH3:16]

참가 물질

4

반응물 2

HCID 121052(1,1'-Biphenyl)-2-carboxaldehydeHCID 4599837Carbamimidoyl-acetic acid ethyl ester

생성물 1

HCID 706316442,6-Diamino-4-(biphenyl-2-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester수율 33%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Upon heating a solution of 9.1 g biphenyl-2-aldehyde and 13.0 g amidinoacetic acid ethyl ester in 200 ml ethanol for two hours, 2,6-diamino-4-(biphenyl-2-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of m.p. 215° (ethanol) is obtained.

출처 및 근거

ORD 기록
ord-cca57af9b6a948d3bc0cac57d86293ef
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04016277

연결된 노트

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