Formaldehyde → HCID 21444650, 화합물

HRID 328252노트

반응식

HRID 328252 반응식
[ClH:1].[C:2]1([C:8]2([OH:14])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15]1(=[O:25])[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][CH2:17][CH2:16]1.[CH2:26]=O>C(O)C>[ClH:1].[C:2]1([C:8]2([OH:14])[CH2:13][CH2:12][N:11]([CH2:26][CH:16]3[CH2:17][CH2:18][C:19]4[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=4)[C:15]3=[O:25])[CH2:10][CH2:9]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 107241-TetraloneHCID 186143834-Phenylpiperidin-4-ol hydrochloride

생성물 1

HCID 21444650HCID 21444650, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

21.35 g. of 4-phenylpiperidin-4-ol hydrochloride, 14.6 g. of 1-tetralone and 10 ml. of 37% formaldehyde solution in 50 ml. of ethanol are heated under reflux for 1 hour. The mixture is evaporated and ether is added to the residue, after which the phases are separated by decantation to give 2-(4-phenyl-4-hydroxypiperidinomethyl)-1-tetralone hydrochloride; m.p. 164°-167°.

후처리

  1. temperatureunder reflux for 1 hour
  2. customThe mixture is evaporated
  3. additionether is added to the residue
  4. customafter which the phases are separated by decantation

출처 및 근거

ORD 기록
ord-2a2bf1ea33f34d9f9595fc7766c7d132
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04016281

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