Acetonitrile → 1-Butylpiperazine

HRID 328275

반응식

HRID 328275 반응식
ClC1N=C2C(C=[CH:7][C:8]([N:12]3[CH:20](OC(OC4C=CC=CC=4)=O)[C:19]4[C:14](=CC=[CH:17][CH:18]=4)[C:13]3=O)=N2)=CC=1.C(#[N:34])C>>[CH2:20]([N:12]1[CH2:8][CH2:7][NH:34][CH2:14][CH2:13]1)[CH2:19][CH2:18][CH3:17]

참가 물질

3

반응물 2

HCID 6342AcetonitrileHCID 233436372-(7-Chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone

생성물 1

HCID 4243221-Butylpiperazine

실험 절차

Following the procedure of Example 15 but starting with 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one (5.1 g.) and 1-t.-butylpiperazine (5 g.) in acetonitrile (31 cc.), 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(4-t.-butylpiperazin-1-yl)carbonyloxy-isoindolin-1-one (3.3 g.), melting at 240° C., is obtained.

출처 및 근거

ORD 기록
ord-70e4aac4a8d64d27a0833124b0baad06
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04016274

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