Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromophenacyl bromide → p-Bromophenacyl 6-hydroxycaproate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromophenacyl bromide | HCID 7454 | — |
| 반응물 | Dicyclohexano-18-crown-6 | HCID 85955 | — |
| 반응물 | 21810-34-4 | HCID 23712826 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | p-Bromophenacyl 6-hydroxycaproate | HCID 13272687 | — |
반응 단계
A mixture of 8.5 g. (50 mmoles) of potassium 6-hydroxycaproate, 13.9 g. (50 mmoles) of p-bromophenacyl bromide, 0.75 g. (2 mmoles) of dicyclohexyl-18 -crown-6 in 500 ml. of acetonitrile is refluxed with stirring for 1 hour and stirred at room temperature overnight. The mixture is filtered and the filtrate evaporated to dryness in vacuo. The residual solid is recrystallized from benzene-hexane mixture affording 14.1 g. of p-bromophenacyl 6-hydroxycarproate, m.p. 79°-81° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04017504 |
| 출처 데이터셋 | uspto-grants-1977_04 |
| ORD ID | ord-a734423e92bc44cb9dbd3621076924e4 |
| 출처 메모 | uspto-grants-1977_04 |