Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 3-isopropyl-3-methyl-3H-imidazo[2,1-a]isoindole-2,5-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | alpha-Isopropyl-alpha-methyl-1,3-dioxo-2-isoindolineacetamide | HCID 4916589 | — |
| 생성물 | 3-isopropyl-3-methyl-3H-imidazo[2,1-a]isoindole-2,5-dione | HCID 2729247 | — |
반응 단계
Following the procedure described in Example 1 and sodium hydride as the base, but substituting (-)-α-isopropyl-α-methyl-1,3-dioxo-2-isoindolineacetamide for the racemic compound, the product (+)-3-isopropyl-3-methyl-5H-imidazo[2,1-a] isoindole-2(3H),5-dione is obtained, melting point 137.5°-139° C, [α]D25 +64.54 (THF, C 0.097).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04017510 |
| 출처 데이터셋 | uspto-grants-1977_04 |
| ORD ID | ord-823febd55a94474993b1d89135b727cd |
| 출처 메모 | uspto-grants-1977_04 |