Ethyl pyruvate → 7-chloro-2-[[1-(ethoxycarbonyl)ethylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

HRID 328382

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:6]=2[CH:20]=1.[C:21]([O:26][CH2:27][CH3:28])(=[O:25])[C:22]([CH3:24])=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:22]([C:21]([O:26][CH2:27][CH3:28])=[O:25])[CH3:24])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:6]=2[CH:20]=1

참가 물질

반응물 2

HCID 12041Ethyl pyruvate

HCID 123908747-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepine

생성물 1

HCID 536573497-chloro-2-[[1-(ethoxycarbonyl)ethylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

실험 절차

In the same manner given in Example 1, 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine and ethyl pyruvate gives 7-chloro-2-[[1-(ethoxycarbonyl)ethylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine as an oily product. NMR (CDCl3) δ1.20 (t, 3, CH2CH3), 2.25 (2, 3, CH3), 4.23 (q. 2, CH2CH3), 4.50 (broad s, 2, 3-CH2), between 6.95 and 7.6 (m, 9, NH and arom H's).

출처 및 근거

ORD 기록: ord-73f436df3b03411f9c51c5a1a890dffd
출처 데이터셋: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04017492

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