Hexane → 2-Allyl-4-fluorophenol

HRID 328628노트

반응식

HRID 328628 반응식
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)C=C.[CH3:12][CH2:13][CH2:14]CCC>>[CH2:14]([C:10]1[CH:9]=[C:8]([F:11])[CH:7]=[CH:6][C:5]=1[OH:4])[CH:13]=[CH2:12]

참가 물질

3

반응물 2

HCID 8058HexaneHCID 6373421-Fluoro-4-(prop-2-en-1-yloxy)benzene

생성물 1

HCID 113441122-Allyl-4-fluorophenol

실험 절차

381.8 parts of oily 4-allyloxy-fluorobenzene are heated in an oil-bath for 8 hours at a temperature of about 245° -250° C. After cooling, the reaction mixture is poured onto 1200 parts of hexane. The mixture is extracted three times with sodium hydroxide solution 20% (total volume of sodium hydroxide: 2000 parts). The aqueous layer is washed with petroleum ether, acidified with 1300 parts of concentrated hydrochloric acid solution and extracted with ether. The extract is dried over calcium chloride, filtered and evaporated. The oily residue is distilled in vacuo, yielding 313.6 parts of 2-allyl-4-fluorophenol; bp 143° C at 48 mm. pressure; nD20 : 1.5225; d2020 : 1.1130.

후처리

  1. temperatureAfter cooling
  2. extractionThe mixture is extracted three times with sodium hydroxide solution 20% (total volume of sodium hydroxide: 2000 parts)
  3. washThe aqueous layer is washed with petroleum ether
  4. extractionextracted with ether
  5. dry with materialThe extract is dried over calcium chloride
  6. filtrationfiltered
  7. customevaporated
  8. distillationThe oily residue is distilled in vacuo

출처 및 근거

ORD 기록
ord-f55a3ce07b2b4eb697710d47253e4d63
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04017631

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