Miconazole → 1-(p-Chlorobenzyl)-3-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazolium iodide

HRID 328633

반응식

HRID 328633 반응식
[Cl:1][C:2]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:3]=1[CH:4]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[Cl:20])[CH2:5][N:6]1[CH:10]=[CH:9][N:8]=[CH:7]1.[Cl:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31][I:32])=[CH:29][CH:28]=1>C(Cl)Cl>[I-:32].[Cl:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31][N+:8]2[CH:9]=[CH:10][N:6]([CH2:5][CH:4]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[C:3]3[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:2]=3[Cl:1])[CH:7]=2)=[CH:29][CH:28]=1

참가 물질

4

반응물 2

HCID 4189MiconazoleHCID 3121671-Chloro-4-(iodomethyl)benzene

생성물 1

HCID 867346501-(p-Chlorobenzyl)-3-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazolium iodide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4.2 Parts of 1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)-phenethyl]imidazole, 3.7 parts of p-chlorobenzyl iodide and 56 parts of methylene chloride are mixed together and stirred at reflux temperature for five hours to obtain a 1-(p-chlorobenzyl)-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium iodide product which remains in the reaction mixture. The reaction mixture is warmed to evaporate off the solvent and to recover the product as residue. The crude product is purified by washing with 2-propanol and crystallizing from a mixture of 4-methyl-2-pentanone and diisopropyl ether, to yield 1-(p-chlorobenzyl)-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium iodide; m.p. 145° -148° C.

후처리

  1. temperatureat reflux temperature for five hours

출처 및 근거

ORD 기록
ord-ff482ff1833744e4bc5f6dfb598ec682
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04017631

연결된 노트

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