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2-Methylpyridine-3-carbonitrile → 1-Amino-3(2-ethyl-pyridyl)-4-methyl-2,5-naphthyridine

HRID 328650
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HRID 328650 반응식
[C:1]([C:3]1[C:4]([CH3:9])=[N:5][CH:6]=[CH:7][CH:8]=1)#[N:2].[C:10]([C:12]1[C:13]([CH2:18][CH3:19])=[N:14][CH:15]=[CH:16][CH:17]=1)#[N:11].[C:20](C1C(CC2C=CC=CC=2)=NC=CC=1)#N.C(C1C(CCC2C=CC=CC=2)=NC=CC=1)#N.C(C1C(CC(C2C=CC=CC=2)C)=NC=CC=1)#N>>[NH2:2][C:1]1[C:3]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[C:9]([CH3:20])=[C:10]([C:12]2[C:13]([CH2:18][CH3:19])=[N:14][CH:15]=[CH:16][CH:17]=2)[N:11]=1
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6

반응물 5

HCID 47383082-Methylpyridine-3-carbonitrileHCID 124287252-(Phenylmethyl)-3-pyridinecarbonitrileHCID 124287283-Cyano-2-phenethylpyridineHCID 154540172-EthylnicotinonitrileHCID 234676323-Cyano-2-phenylpropylpyridine

생성물 1

HCID 234676821-Amino-3(2-ethyl-pyridyl)-4-methyl-2,5-naphthyridine

실험 절차

In a similar manner by substituting the 3-cyano-2-methylpyridine with equivalent quantities of 3-cyano-2-ethylpyridine, 3-cyano-2-benzylpyridine, 3-cyano-2-phenethylpyridine and 3-cyano-2-phenylpropylpyridine and by substantially following the procedure of this example there is produced 1-amino-3(2-ethyl-pyridyl)-4-methyl-2,5-naphthyridine; 1-amino-3-(2-benzyl-3-pyridyl)-4-phenyl-2,5-naphthyridine; 1-amino-3-(2-benzyl-3-pyridyl)-4-phenyl-2,5-naphthyridine; 1-amino-3-(2-phenethyl-3-pyridyl)-4-benzyl-2,5-naphthyridine; 1-amino-3-(2-phenylpropyl-3-pyridyl)-4-phenethyl-2,5-naphthyridine, respectively. Similarly, in those instances wherein it is desired to produce those compounds bearing substituents on the pyridyl, phenyl and benzyl moieties of the foregoing then, as expected, the appropriately substituted starting reactants are then similarly reacted.

출처 및 근거

ORD 기록
ord-75927698f2604792952013a1c30419e7
출처 데이터셋
uspto-grants-1977_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04017500

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