Diketene → N-(2-Methylpropanoyl)-3-oxobutanamide

HRID 328677노트

반응식

HRID 328677 반응식
[C:1]([NH2:6])(=[O:5])[CH:2]([CH3:4])[CH3:3].[CH2:7]=[C:8]1[O:12][C:10](=[O:11])[CH2:9]1>>[C:10]([NH:6][C:1](=[O:5])[CH:2]([CH3:4])[CH3:3])(=[O:11])[CH2:9][C:8]([CH3:7])=[O:12]

참가 물질

3

반응물 2

HCID 12661DiketeneHCID 68424Isobutyramide

생성물 1

HCID 12682092N-(2-Methylpropanoyl)-3-oxobutanamide수율 38.7%

실험 절차

A 250 ml, three-necked, round bottom flask, was equipped with a condenser, drying tube, mechanical stirrer, gas inlet tube, thermometer and heating mantle. Toluene (100 ml) was introduced and hydrogen chloride gas was bubbled through the solvent until the solution was saturated. Isobutyramide (8.70 g, 0.10 mole) was added and the mixture was heated to 92°. Diketene (8.40 g, 0.10 mole) was added over a 6 minute period and after heating for 15 minutes, a 38.7% yield of N-acetoacetylisobutyramide was obtained.

후처리

  1. customA 250 ml, three-necked, round bottom flask, was equipped with a condenser
  2. customdrying tube, mechanical stirrer, gas inlet tube
  3. temperaturethermometer and heating mantle
  4. additionToluene (100 ml) was introduced
  5. customhydrogen chloride gas was bubbled through the solvent until the solution
  6. temperaturethe mixture was heated to 92°
  7. temperatureafter heating for 15 minutes

출처 및 근거

ORD 기록
ord-d58c3049331d42269842d30240302ecd
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04018771

반응 노트

불러오는 중…