1-(2-Methoxyphenyl)piperazine → HCID 70619452, 화합물

HRID 328697노트

반응식

HRID 328697 반응식
[O:1]1[CH:11]2[CH:2]1[CH2:3][C:4]1[C:5]([O:14][CH3:15])=[CH:6][CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[CH2:10]2.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1.C(O)(C)C>C1(C)C(C)=CC=CC=1>[CH3:15][O:14][C:5]1[CH:6]=[CH:7][C:8]([O:12][CH3:13])=[C:9]2[C:4]=1[CH2:3][C@@H:2]([N:27]1[CH2:26][CH2:25][N:24]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[O:17][CH3:16])[CH2:29][CH2:28]1)[C@H:11]([OH:1])[CH2:10]2

참가 물질

5

반응물 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 3776IsopropanolHCID 123670031a,2,7,7a-Tetrahydro-3,6-dimethoxynaphth[2,3-b]oxirene

생성물 1

HCID 70619452HCID 70619452, 화합물수율 50.4%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

A solution of 4.12 g of 6,7-epoxy-5,6,7,8-tetrahydro-1,4-dimethoxynaphthalene, 4.81 g of 1-(o-methoxyphenyl)piperazine, and 1.53 ml of isopropyl alcohol in 20 ml of xylene is refluxed under nitrogen for 19 hours. The xylene is removed in vacuo and the residue triturated with ether to give 4.01 g of crude material. Two recrystallizations of this material from ethyl acetate yield 2.5 g of the title compound, melting point 182°-183° C.

후처리

  1. customThe xylene is removed in vacuo
  2. customthe residue triturated with ether

출처 및 근거

ORD 기록
ord-d2b0115da3c548ff92c9e820240182a3
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04018773

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