Thionyl Chloride → Ethyl 8-(2-chloroethylthio)-12-acetoxyheptadecanoate

HRID 328770노트

반응식

HRID 328770 반응식
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][S:8][CH:9]([CH2:21][CH2:22][CH2:23][CH:24]([O:30][C:31](=[O:33])[CH3:32])[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]>C1C=CC=CC=1>[Cl:3][CH2:6][CH2:7][S:8][CH:9]([CH2:21][CH2:22][CH2:23][CH:24]([O:30][C:31](=[O:33])[CH3:32])[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 21317600HCID 21317600, 화합물

생성물 1

HCID 21317532Ethyl 8-(2-chloroethylthio)-12-acetoxyheptadecanoate

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Thionyl chloride (13.1 g., 0.11 mole) is added dropwise with stirring to a solution of ethyl 8-(2-hydroxyethylthio)-12-acetoxyheptadecanoate (43.2 g., 0.10 mole) in benzene (150 ml.). The solution is heated at reflux for 2 hours. Then, the solvent and excess thionyl chloride are removed by evaporation in vacuo to leave the title compound as an orange yellow residual oil.

후처리

  1. temperatureThe solution is heated
  2. temperatureat reflux for 2 hours
  3. customThen, the solvent and excess thionyl chloride are removed by evaporation in vacuo

출처 및 근거

ORD 기록
ord-de56ea68853742879cd6376df4bf57e9
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04018802

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