참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1-(Propan-2-yl)azetidin-3-ol | HCID 544677 | — |
| 반응물 | 1-Phenoxyphenol | HCID 20517352 | — |
| 생성물 | 1-(p-Phenoxyphenoxy)-3-(iso-propylamino)-2-propanol | HCID 20517315 | 58% |
반응 단계
To a mixture of 5.8 parts of 1-(iso-propyl)-3-azetidinol and 9.3 parts of 1-phenoxyphenol 0.1 part of sodium hydroxide was added, and the mixture was heated under nitrogen gas at 160° C. for 18 hours. The reaction mixture was cooled and extracted with ether. The extract was washed in water and then the solvent was distilled off. Recrystallization of the residue gave 16.1 parts of 1-(p-phenoxyphenoxy)-3-(iso-propylamino)-2-propanol having a melting point of 72°-74° C. The yield was 58%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04018824 |
|---|
| 출처 데이터셋 | uspto-grants-1977_04 |
|---|
| ORD ID | ord-439dc4399852448982e7db8374c60e24 |
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| 출처 메모 | uspto-grants-1977_04 |
|---|
