Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5,6,7,8-Tetrahydro-1-naphthol → Nadolol EP Impurity G
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5,6,7,8-Tetrahydro-1-naphthol | HCID 68258 | — |
| 반응물 | 1-tert-Butyl-3-hydroxyazetidine | HCID 287986 | — |
| 생성물 | Nadolol EP Impurity G | HCID 12445684 | — |
반응 단계
1-(tert.-butyl)-3-azetidinol and 5,6,7,8-tetrahydro-α-naphthol were reacted in the same manner as in Example 1 to form 1-(5,6,7,8-tetrahydro-α-naphthoxy)-3-(tert.-butylamino)-2-propanol. A hydrochloric acid gas was blown into the obtained propanol. As a result 1-(5,6,7,8-tetrahydro-1-naphthoxy)-3-(tert.-butylamino)-2-propanol hydrochloride having a melting point of 148°-150° C was obtained. The yield was 70%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04018824 |
| 출처 데이터셋 | uspto-grants-1977_04 |
| ORD ID | ord-f059d5e8e570480fbb02be2123d4e8fa |
| 출처 메모 | uspto-grants-1977_04 |