Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
10-(3-Chloropropyl)-2-(trifluoromethyl)-10H-phenothiazine → 2-Trifluoromethyl-10-[3-(4-[4-hydroxybutoxy]-piperidino)-propyl]-phenothiazine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 10-(3-Chloropropyl)-2-(trifluoromethyl)-10H-phenothiazine | HCID 74294 | — |
| 반응물 | 4-(4-Piperidyloxy)-butanol | HCID 21440902 | — |
| 생성물 | 2-Trifluoromethyl-10-[3-(4-[4-hydroxybutoxy]-piperidino)-propyl]-phenothiazine hydrochloride | HCID 21440928 | 39% |
반응 단계
Using the procedure of Example XI, 49.7 g (0.145 mole) of 2-trifluoromethyl-10-(3-chloropropyl)-phenothiazine and 25.5 g (0.145 mole) of 4-(4-piperidyloxy)-butanol were reacted to obtain 29 g (39% yield) of 2-trifluoromethyl-10-[3-(4-[4-hydroxybutoxy]-piperidino)-propyl]-phenothiazine hydrochloride in the form of white crystals melting at 67° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04018922 |
| 출처 데이터셋 | uspto-grants-1977_04 |
| ORD ID | ord-c91d8cc0d323414aa71221798c7b4f3f |
| 출처 메모 | uspto-grants-1977_04 |