Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Hydroxyacetamide → 2-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Hydroxyacetamide | HCID 69021 | — |
| 반응물 | 2-(4-Chloro-2-methylphenoxy)acetaldehyde | HCID 12391459 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone | HCID 12391492 | 18.2% |
반응 단계
A solution containing 4.6 g (0.025 mole) of (4-chloro-2-methylphenoxy)acetaldehyde and 2.1 g (0.028 mole) of glycolamide in 25 ml of tetrahydrofuran and 25 ml of ether was allowed to stand at ambient temperature for 24 hours. The resulting product was washed with 5% sodium carbonate and water, dried and purified by silica chromatography to give 1.1 g of 2-(4-chloro-2-methylphenoxymethyl)-4-oxazolidinone as a white crystalline solid melting at 109°-112°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04019892 |
| 출처 데이터셋 | uspto-grants-1977_04 |
| ORD ID | ord-adea834a71ad4136bf95e9e233446459 |
| 출처 메모 | uspto-grants-1977_04 |