Ammonia → 3,5-Dichloro-2-hydroxybenzamide

HRID 329193노트

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HRID 329193 반응식
[Cl:1][C:2]1[CH:11]=[C:10]([Cl:12])[CH:9]=[C:4]([C:5](OC)=[O:6])[C:3]=1[OH:13].[NH3:14]>>[Cl:1][C:2]1[CH:11]=[C:10]([Cl:12])[CH:9]=[C:4]([C:5]([NH2:14])=[O:6])[C:3]=1[OH:13]

참가 물질

3

반응물 2

HCID 222Ammonia2회HCID 82082Benzoic acid, 3,5-dichloro-2-hydroxy-, methyl ester

생성물 1

HCID 125631993,5-Dichloro-2-hydroxybenzamide

반응 조건

온도
25 °C

실험 절차

A 1 liter Parr autoclave was charged with 221 g. (1 mole) -dichlorophenyl)- of methyl 3,5-dichlorosalicylate and 140 g. (8 moles) of anhydrous ammonia. The mixture was stirred at 25° C for 24 hours. After venting excess ammonia, the product was ground to a fine powder and triturated with boiling chloroform. The mixture was filtered while hot and the residue weighed 153 g. Analysis by infrared, gas chromatography, and nuclear magnetic resonance confirmed that the product was 3,5-dichlorosalicylamide.

후처리

  1. additionA 1 liter Parr autoclave was charged with 221 g
  2. customtriturated with boiling chloroform
  3. filtrationThe mixture was filtered while hot and the residue

출처 및 근거

ORD 기록
ord-a66591768d304c25bc90ad70e522d405
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04020081

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