Potassium Carbonate → HCID 21438986, 화합물

HRID 329204

반응식

HRID 329204 반응식
[CH2:1]([O:3][C:4]1[S:5][C:6]([C:10]#[N:11])=[C:7]([OH:9])[N:8]=1)[CH3:2].C(=O)([O-])[O-].[K+].[K+].[P:18](Cl)([O:22][CH3:23])([O:20][CH3:21])=[O:19]>CC(C)=O>[CH2:1]([O:3][C:4]1[S:5][C:6]([C:10]#[N:11])=[C:7]([O:9][P:18]([O:22][CH3:23])([O:20][CH3:21])=[O:19])[N:8]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 101863Phosphorochloridic acid, dimethyl esterHCID 214389692-Ethoxy-4-hydroxythiazole-5-carbonitrile

생성물 1

HCID 21438986HCID 21438986, 화합물수율 57.5%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 17 g of 2-ethoxy-4hydroxy-5-cyano-thiazole, 14 g of potassium carbonate, 13 g of O,O-dimethyl chlorophosphate and 150 ml of acetone was stirred for 3 hours at room temperature and the mixture was concentrated to dryness. The residue was added to an aqueous sodium chloride solution which was then extracted with ethyl ether. The ether extracts were washed with an aqueous 2% sodium hydroxide solution, dried and evaporated to dryness to obtain 14.4 g of 2-ethoxy-4-dimethoxyphosphoryloxy-5-cyano-thiazole as an oil with a refractive index n D 23 = 1.5056.

후처리

  1. concentrationthe mixture was concentrated to dryness
  2. additionThe residue was added to an aqueous sodium chloride solution which
  3. extractionwas then extracted with ethyl ether
  4. washThe ether extracts were washed with an aqueous 2% sodium hydroxide solution
  5. customdried
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-d75fb1e8e60041f89ca8905dde25c868
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04020076

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