Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 2,6-Dimethoxymethyl-4-(4'-methylmercaptophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 4-(Methylthio)benzaldehyde | HCID 76985 | — |
| 반응물 | Ethyl 4-methoxy-3-oxobutanoate | HCID 12645099 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2,6-Dimethoxymethyl-4-(4'-methylmercaptophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 68121248 | 50% |
반응 단계
7.6 g of 4-methylmercaptobenzaldehyde, 16 g of γ-methoxyacetoacetic acid ethyl ester and 6 ml of aqueous concentrated ammonia in 30 ml of ethanol are heated to the boil for 6-8 hours, and 2,6-dimethoxymethyl-4-(4'-methylmercaptophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained in the form of beige crystals of melting point 136°-138° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04020178 |
| 출처 데이터셋 | uspto-grants-1977_04 |
| ORD ID | ord-73b84b635c304d208b0b8b973465f8bb |
| 출처 메모 | uspto-grants-1977_04 |