Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea

HRID 329341

반응식

HRID 329341 반응식
C(C1C=NC(C2C=CC([OH:23])=CC=2)=NC=1)CCCCCCCCC.C([C@H]1CC[C@H](C(O)=O)CC1)CCCC.[CH:38]1([N:44]=[C:45]=[N:46][CH:47]2[CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]2)[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]1>ClCCl>[CH:47]1([NH:46][C:45]([NH:44][CH:38]2[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]2)=[O:23])[CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]1

참가 물질

5

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 135585902Phenol, 4-(5-decyl-2-pyrimidinyl)-HCID 178444557HCID 178444557, 화합물

생성물 1

HCID 4277N,N'-Dicyclohexylurea

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 35.4 g of 4-(5-decylpyrimidin-2-yl)phenol, 22.5 g of trans-4-pentylcyclohexanecarboxylic acid and 23.4 g of N,N'-dicyclohexylcarbodiimide in 600 ml of dichloromethane is stirred at 20° C. for 12 hours. The N,N'-dicyclohexylurea formed is filtered off, and the filtrate is chromatographed over 5 kg of silica gel using dichloromethane. The product-containing fraction gives 21.5 g of colorless crystals after recrystallization from n-hexane.

출처 및 근거

ORD 기록
ord-52fde18c50ee408583b6415095779c69
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04891151

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