2-Bromo-1-[3,5-di(tert-butyl)-4-hydroxyphenyl]ethan-1-one → 2H-Imidazo(2,1-b)(1,3,4)thiadiazin-6(7H)-one, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-, hydrobromide

HRID 329386

반응식

HRID 329386 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[C:8]([OH:15])=[C:7]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:6]=1)=O.[NH2:20][N:21]1[C:25](=[O:26])[CH2:24][NH:23][C:22]1=[S:27]>>[BrH:1].[C:11]([C:9]1[CH:10]=[C:5]([C:3]2[CH2:2][S:27][C:22]3=[N:23][CH2:24][C:25](=[O:26])[N:21]3[N:20]=2)[CH:6]=[C:7]([C:16]([CH3:19])([CH3:18])[CH3:17])[C:8]=1[OH:15])([CH3:14])([CH3:13])[CH3:12]

참가 물질

3

반응물 2

HCID 6161612-Bromo-1-[3,5-di(tert-butyl)-4-hydroxyphenyl]ethan-1-oneHCID 142110443-Amino-2-sulfanylideneimidazolidin-4-one

생성물 1

HCID 30883862H-Imidazo(2,1-b)(1,3,4)thiadiazin-6(7H)-one, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-, hydrobromide

실험 절차

34.4 g (0.11 mol) of 2-bromo-1-(3,5-di-tert.butyl-4-hydroxyphenyl)-ethanone from Example 1(a) and 13.8 g (0.11 mol) of 1-amino-2-thioxo-5-imidazolidinone from step (a) were heated at 90° C. for 30 minutes in 300 ml of glacial acelic acid. After cooling, the precipitate was filtered off and washed with 250 ml of ethyl acetate, and the crystals were dried in vacuo over phosphorus pentoxide.

후처리

  1. temperatureAfter cooling
  2. filtrationthe precipitate was filtered off
  3. washwashed with 250 ml of ethyl acetate
  4. dry with materialthe crystals were dried in vacuo over phosphorus pentoxide

출처 및 근거

ORD 기록
ord-54c15c30e1fa4ef3b2056b4250981e34
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04891374

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