Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → ethyl 6-[p-[5-(1H-imidazo[4,5-b]pyridin-2-ylthio)pentyloxy]phenoxy]-2,2-dimethylhexanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Ethyl 6-[p-(5-bromopentyloxy)phenoxy]-2,2-dimethylhexanoate | HCID 14851566 | — |
| 반응물 | HCID 178527819 | HCID 178527819 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | ethyl 6-[p-[5-(1H-imidazo[4,5-b]pyridin-2-ylthio)pentyloxy]phenoxy]-2,2-dimethylhexanoate | HCID 14327306 | 32.4% |
반응 단계
To a mixture of 570 mg 2-mercapto-1H-imidazo[4,5-b]pyridine and 18 ml methanol, was added a mixture of 166 mg sodium hydroxide, 6 ml water and 1.8 g ethyl 6-[p-(5-bromopentyloxy)phenoxy]-2,2-dimethylhexanoate. The resulting mixture was heated under reflux for 12 hours, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography, affording 610 mg ethyl 6-[p-[5-(1H-imidazo[4,5-b]pyridin-2-ylthio)pentyloxy]phenoxy]-2,2-dimethylhexanoate as waxy solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04891432 |
| 출처 데이터셋 | uspto-grants-1990_01 |
| ORD ID | ord-519a95a668a94030af7035c3756cf998 |
| 출처 메모 | uspto-grants-1990_01 |