Thiazole → 3-[7-(trans-3-Hexadecyloxytetrahydropyran-2-ylmethoxy)heptyl]thiazolium methanesulfonate

HRID 329497노트

반응식

HRID 329497 반응식
[CH3:1][S:2]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][CH2:14][C@H:15]1[C@H:20]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH2:19][CH2:18][CH2:17][O:16]1)(=[O:4])=[O:3].[S:38]1[CH:42]=[CH:41][N:40]=[CH:39]1>C1(C)C=CC=CC=1>[CH3:1][S:2]([O-:5])(=[O:4])=[O:3].[CH2:22]([O:21][C@@H:20]1[CH2:19][CH2:18][CH2:17][O:16][C@H:15]1[CH2:14][O:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][N+:40]1[CH:41]=[CH:42][S:38][CH:39]=1)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]

참가 물질

4

반응물 2

HCID 9256ThiazoleHCID 186371317-(trans-3-Hexadecyloxytetrahydropyran-2-ylmethoxy)heptyl methanesulfonate

생성물 1

HCID 186371263-[7-(trans-3-Hexadecyloxytetrahydropyran-2-ylmethoxy)heptyl]thiazolium methanesulfonate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

1.20 g of the methanesulfonate [prepared as described in step (a) above] and 1.56 ml of thiazole were dissolved in 3 ml of toluene, and the solution was stirrd on an oil bath kept at 70° C. for 5 days. At the end of this time, the mixture was allowed to cool, the solvent was distilled off under reduced pressure, and the residue was subjected to column chromatography through 40 g of silica gel. 0.741 g of the title compound was obtained as a viscous oil from the fractions eluted with a 60:35:5 by volume mixture of methylene chloride, methanol and water.

후처리

  1. customthe solution was stirrd on an oil bath
  2. temperatureto cool
  3. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-30aca703d20b46deb31f4950a25bb076
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04891363

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