Dicyclohexylcarbodiimide → HCID 15052024, 화합물

HRID 329568노트

반응식

HRID 329568 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:25](=[O:26])[C:24]([CH3:28])([CH3:27])[CH2:23][O:22]2)=[CH:16][CH:15]=1)=O)([OH:3])=[O:2].C1(N=C=NC2CCCCC2)CCCCC1>C1(C)C=CC=CC=1>[C:1]1(=[O:3])[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[CH:10]=[C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][N:21]3[C:25](=[O:26])[C:24]([CH3:27])([CH3:28])[CH2:23][O:22]3)=[CH:16][CH:15]=2)[O:2]1

참가 물질

4

반응물 2

HCID 10868DicyclohexylcarbodiimideHCID 15052016HCID 15052016, 화합물

생성물 1

HCID 15052024HCID 15052024, 화합물수율 109.8%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 0.57 gram (0.0015 mole) of 2-[[4-[(2-carboxyphenylmethyl)carbonylamino]phenyl]methyl]-4,4-dimethyl-3-isoxazolidinone in 100 mL of toluene was cooled in an ice bath, and, with stirring, 0.33 gram (0.0016 mole) of dicyclohexylcarbodiimide was added in one portion. Upon completion of addition the reaction mixture was allowed to warm to ambient temperature where it was stirred for 16 hours. The resultant solid was collected by filtration to yield 0.60 gram of 2-[[4-[(1H-2-benzopyran-1-one-3-yl)amino]phenyl]methyl]-4,4-dimethyl-3-isoxazolidinone; m.p. 175°-177° C.

후처리

  1. additionUpon completion of addition the reaction mixture
  2. stirringwas stirred for 16 hours
  3. filtrationThe resultant solid was collected by filtration

출처 및 근거

ORD 기록
ord-ec648fc7aae44292a197c6bb9386d8b1
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04892578

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