Sodium Carbonate → 2-Methoxy-3,4-dimethyl-2-cyclopenten-1-one

반응식

[CH3:1][O:2][CH2:3][C:4](=[O:15])[CH:5]([CH:10]([CH3:14])[C:11]([CH3:13])=O)C(OC)=O.C([O-])([O-])=O.[Na+].[Na+]>>[CH3:1][O:2][C:3]1[C:4](=[O:15])[CH2:5][CH:10]([CH3:14])[C:11]=1[CH3:13]

참가 물질

반응물 2

HCID 10340Sodium Carbonate

HCID 19871668Methyl 4-methoxy-2-(1-methylacetonyl)-acetoacetate

생성물 1

HCID 198716652-Methoxy-3,4-dimethyl-2-cyclopenten-1-one

실험 절차

2.16 g (10 mmol) of methyl 4-methoxy-2-[1-methylacetonyl]-acetoacetate are held at reflux temperature for 2 hours with 21.2 ml (5 mmol) of 2.5% Na2CO3 solution. The reaction mixture is extracted 3 times with 25 ml of CH2Cl2 each time. The combined organic phases are dried over magnesium sulphate and concentrated on a rotary evaporator to give 1.40 g (100%) or 2-methoxy-3,4-dimethyl-2-cyclopenten-1-one, content 96%.

후처리

extractionThe reaction mixture is extracted 3 times with 25 ml of CH2Cl2 each time
dry with materialThe combined organic phases are dried over magnesium sulphate
concentrationconcentrated on a rotary evaporator

출처 및 근거

ORD 기록: ord-ad4afb7e1b7d4657a997aac876e0c9f6
출처 데이터셋: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04892966

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