2,2-Difluoro-4-pentenoic acid → 2,2-Difluoro-4-pentenoyl chloride

HRID 329820

반응식

HRID 329820 반응식
[F:1][C:2]([F:9])([CH2:6][CH:7]=[CH2:8])[C:3](O)=[O:4].[P](Cl)(Cl)(Cl)[Cl:11]>>[F:1][C:2]([F:9])([CH2:6][CH:7]=[CH2:8])[C:3]([Cl:11])=[O:4]

참가 물질

3

반응물 2

HCID 119546562,2-Difluoro-4-pentenoic acidHCID 178479782HCID 178479782, 화합물

생성물 1

HCID 136650492,2-Difluoro-4-pentenoyl chloride

실험 절차

In a round-bottomed flask with a distillation head, 57.2 g (0.42 mol) of 2,2-difluoro-4-pentenoic acid are slowly added dropwise to 102.0 g of phosphorus tetrachloride. After stirring for 20 minutes at RT, the reaction mixture is distilled, 42.1 g (65%) of the acid chloride passing over as a colourless oil at 92°-98° C./988 mbar. 1H-NMR (60 MHz, CDCl3): 6.0-5.0 (m, 3H); 2.9 (d x t, J=6; 16 Hz, 2H).

후처리

  1. distillationthe reaction mixture is distilled
  2. customat 92°-98° C.

출처 및 근거

ORD 기록
ord-31ae817039cf47879e37a9754eab2655
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04892962

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