Ethanol → Ethyl 2,2-difluoropent-4-enoate

HRID 329821

반응식

[F:1][C:2]([F:9])([CH2:6][CH:7]=[CH2:8])[C:3]([OH:5])=[O:4].[CH2:10](O)[CH3:11]>>[F:1][C:2]([F:9])([CH2:6][CH:7]=[CH2:8])[C:3]([O:5][CH2:10][CH3:11])=[O:4]

참가 물질

반응물 2

HCID 702Ethanol

HCID 119546562,2-Difluoro-4-pentenoic acid

생성물 1

HCID 14049931Ethyl 2,2-difluoropent-4-enoate

실험 절차

Analogously to Example 1, 38.5 g (0.28 mol) of 2,2-difluoro-4-pentenoic acid are esterified with ethanol. Yield: 41.3 g (89%) of a colourless oil of boiling point 55°-57° C./52 mbar, 1H-NMR (60 MHz, CDCl3): 6.1-5.0 (m, 3H); 4.30 (qa, J=7 Hz, 2H); 2.85 (d x t, J=16 Hz, 2H); 1.35 (t, J=7 Hz, 3H).

출처 및 근거

ORD 기록: ord-7691782a90d74fd8a5dddbb781f8feca
출처 데이터셋: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04892962

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