Putrescine → 1-(4-Aminobutylamino)-4-methoxyanthracene-9,10-dione

HRID 330060

반응식

HRID 330060 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][NH2:6].[CH3:7][O:8][C:9]1[C:22]2[C:21](=[O:23])[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14](=[O:24])[C:13]=2[C:12](OC)=[CH:11][CH:10]=1>C(Cl)Cl>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:12]1[C:13]2[C:14](=[O:24])[C:15]3[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:21](=[O:23])[C:22]=2[C:9]([O:8][CH3:7])=[CH:10][CH:11]=1

참가 물질

4

반응물 2

HCID 1045PutrescineHCID 2660541,4-Dimethoxyanthraquinone

생성물 1

HCID 133805781-(4-Aminobutylamino)-4-methoxyanthracene-9,10-dione수율 50.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1,4-Diaminobutane (1.65 g, 19 mmol) was added to a solution of 1,4-dimethoxyanthracene-9,10-dione (1.0 g, 3.7 mmol) in CH2Cl2 (700 ml). After seven, hours of irradiation, the solvent was removed and the residue chromatographed on silica gel. Starting material was eluted with CHCl3 and the product with 5% CH3OH in CHCl3. A purple solid (0.61 g, 50%) was obtained which was converted to the benzyloxycarbonyl derivative.

후처리

  1. customAfter seven, hours of irradiation
  2. customthe solvent was removed
  3. customthe residue chromatographed on silica gel
  4. washStarting material was eluted with CHCl3

출처 및 근거

ORD 기록
ord-cb9650b945854228a55b0887a0509362
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04894451

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