Acetyl chloride → Benzoic acid, 3-methoxy-4-methyl-, methyl ester

HRID 330142

반응식

HRID 330142 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[CH3:12])[C:6]([OH:8])=[O:7].[C:13](Cl)(=O)C>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[CH3:12])[C:6]([O:8][CH3:13])=[O:7]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 815794-Methyl-m-anisic acid

생성물 1

HCID 591123Benzoic acid, 3-methoxy-4-methyl-, methyl ester수율 98%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 3-methoxy-4-methylbenzoic acid (6.0 g) in methanol (120 ml) was treated with acetyl chloride (6 ml) and stirred for 36 hours. The solution was evaporated. The residue was dissolved in methanol (100 ml) and the solution evaporated. This procedure was repeated to give methyl 3-methoxy-4-methylbenzoate (6.34 g, 98%) as a colorless oil; NMR (80 MHz, CDCl3): 2.2(s, 3H, CH3), 3.9(2s, 6H, 2×OCH3), 7.1(d, 1H), 7.5(m, 2H).

후처리

  1. customThe solution was evaporated
  2. dissolutionThe residue was dissolved in methanol (100 ml)
  3. customthe solution evaporated

출처 및 근거

ORD 기록
ord-1337eee3efaa4aa7ba9e927d7718e6ca
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04894386

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