Sodium Cyanide → HCID 13501071, 화합물

HRID 330261노트

반응식

HRID 330261 반응식
Br[CH2:2][C:3]1[C:12]([CH3:13])=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1.[C-:14]#[N:15].[Na+]>O>[CH3:13][C:12]1[C:3]([CH2:2][C:14]#[N:15])=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2

참가 물질

4

반응물 2

HCID 8929Sodium CyanideHCID 27530932-(Bromomethyl)-3-methylnaphthalene

생성물 1

HCID 13501071HCID 13501071, 화합물수율 99%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A suspension of 2-bromomethyl3-methylnaphthalene (2.87 g, 12.2 mmol) and NaCN (652 mg, 13.3 mmol) in CH3CH/H2O (9:1, 125 mL) was heated to reflux for 1 hour. Upon warming, the suspension became homogeneous. After cooling to room temperature, the volatiles were removed from the reaction mixture in vacuo and the residue was partitioned between 2O (150 mL) and CH2Cl2 (150 mL). The aqueous phase was extracted with CH2Cl2 (1×150 mL). The combined organic layers were dried (Na2SO4) and concentrated in vacuo to give the title compound as a white solid (2.18 g, 99%). This material was of sufficient purity to be used as such in the next step.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 1 hour
  3. temperatureUpon warming
  4. customthe volatiles were removed from the reaction mixture in vacuo
  5. customthe residue was partitioned between 2O (150 mL) and CH2Cl2 (150 mL)
  6. extractionThe aqueous phase was extracted with CH2Cl2 (1×150 mL)
  7. dry with materialThe combined organic layers were dried (Na2SO4)
  8. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-1a41d8d0dfd640d6b7d006b46d689e4b
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04895861

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