HCID 13304948, 화합물 → HCID 19989904, 화합물

반응식

[CH2:1]([C:3]1[C:4]([O:15][CH3:16])=[N:5][C:6]2[N:7]([CH:10]=[C:11]([CH:13]=[O:14])[N:12]=2)[C:8]=1[CH3:9])[CH3:2].[O:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]1[O:23][CH2:24][C:25]#[C:26][Mg]Br>>[CH2:1]([C:3]1[C:4]([O:15][CH3:16])=[N:5][C:6]2[N:7]([CH:10]=[C:11]([C:13](=[O:14])[C:26]#[C:25][CH2:24][O:23][CH:18]3[CH2:19][CH2:20][CH2:21][CH2:22][O:17]3)[N:12]=2)[C:8]=1[CH3:9])[CH3:2]

참가 물질

반응물 2

HCID 13304948HCID 13304948, 화합물

HCID 178419646HCID 178419646, 화합물

생성물 1

HCID 19989904HCID 19989904, 화합물

실험 절차

6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidin-2-carboxaldehyde and 3-(tetrahydropyran-2-yloxy)-1-propynyl-magnesium bromide [J. Chem. Soc., 1950, 3646] were reacted by the method of Step A of Example 1 to obtain 1-(6-ethyl-7-methoxy-5-methylimidazol[1,2-a]pyrimidin-2-yl)-4-(tetrahydropyran-2-yloxy)-2-butyn-1-one.

출처 및 근거

ORD 기록: ord-cae4c9cd73494e628bc09d6e3a2311d8
출처 데이터셋: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04895866

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