Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → N-(t-butyloxycarbonyl)-4-benzyloxy-L-phenylalanine 3-pyridylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Aminopyridine | HCID 10009 | — |
| 반응물 | Ethyl chloroformate | HCID 10928 | — |
| 반응물 | O-benzyl-N-((tert-butoxy)carbonyl)-L-tyrosine | HCID 98763 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-(t-butyloxycarbonyl)-4-benzyloxy-L-phenylalanine 3-pyridylamide | HCID 54368616 | 22.6% |
반응 단계
N-(t-butyloxycarbonyl)-4-benzyloxy-L-phenylalanine (I) (3.71 g) was dissolved in dry tetrahydrofuran (100 ml) and, under ice cooling, triethylamine (1.5 ml) was added thereto. After stirring for 15 minutes, ethyl chlorocarbonate (1.10 g) was added, followed by stirring for 30 minutes. To this solution was added 3-aminopyridine (0.94 g) and the reaction was carried out at room temperature for 7 hours. The solid was filtered off and the filtrate was concentrated under reduced pressure. The residue was extracted with ethyl acetate. After a conventional post-treatment, N-(t-butyloxycarbonyl)-4-benzyloxy-L-phenylalanine 3-pyridylamide (II) (1.01 g) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04895842 |
| 출처 데이터셋 | uspto-grants-1990_01 |
| ORD ID | ord-7ef08bdefa5e47119bc105eb466ad06b |
| 출처 메모 | uspto-grants-1990_01 |