Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenyl thioxochloroformate → 2-Isothiocyanato-4,6-dimethoxypyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenyl thioxochloroformate | HCID 70498 | — |
| 반응물 | 4,6-Dimethoxy-N-(trimethylsilyl)pyrimidin-2-amine | HCID 19868312 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-Isothiocyanato-4,6-dimethoxypyrimidine | HCID 14253942 | 43.5% |
반응 단계
A solution of 45.0 g of 4,6-dimethoxy-2-trimethylsilylaminopyrimidine and 35.0 g of phenyl chlorothionocarbonate in 300 ml of acetonitrile is refluxed for 10 hours. The reaction solution is concentrated under reduced pressure to remove acetonitrile. Toluene (300 ml) is added to the residue and filtered to remove insoluble substance. The filtrate is concentrated under reduced pressure and purified by silica gel column-chromatography (eluent: ethyl acetate:hexane =1:1). 4,6-Dimethoxy-2-isothiocyanatopyrimidine (17.0 g) is obtained from the first eluate. mp 85°~86° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04897105 |
| 출처 데이터셋 | uspto-grants-1990_01 |
| ORD ID | ord-af1813f5d4054331afb5433f76507d3a |
| 출처 메모 | uspto-grants-1990_01 |