Tetrahydrofuran → 1-[(4-Methoxyphenyl)diphenylmethoxy]-3-[4-(phenylmethoxy)-phenoxy]-2-propanol

HRID 330499노트

반응식

HRID 330499 반응식
[C:1]1([CH2:7][O:8][C:9]2[CH:20]=[CH:19][C:12]([O:13][CH2:14][CH:15]([OH:18])[CH2:16][OH:17])=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO[C:23]1[CH:42]=[CH:41][CH:40]=[CH:39][C:24]=1[C:25](Cl)([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[O:43]1CCC[CH2:44]1>N1C=CC=CC=1>[CH3:44][O:43][C:29]1[CH:30]=[CH:31][C:26]([C:25]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)([C:24]2[CH:23]=[CH:42][CH:41]=[CH:40][CH:39]=2)[O:17][CH2:16][CH:15]([OH:18])[CH2:14][O:13][C:12]2[CH:19]=[CH:20][C:9]([O:8][CH2:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:10][CH:11]=2)=[CH:27][CH:28]=1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 2310801,2-Propanediol, 3-((p-benzyloxy)phenoxy)-HCID 14429619Methoxytrityl chloride

생성물 1

HCID 198685871-[(4-Methoxyphenyl)diphenylmethoxy]-3-[4-(phenylmethoxy)-phenoxy]-2-propanol

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 18.9 g of 3-[4-(phenylmethoxy)-phenoxy]-1,2-propanediol in 50 ml of pyridine and 24 ml of tetrahydrofuran was added 25.57 g of methoxy trityl chloride in several portions. This mixture was stirred for 24 hours and the solvents removed under reduced pressure. The residue was dissolved in chloroform, washed with aqueous sodium bicarbonate, then water, dried and evaporated, giving 30 g of the desired compound.

후처리

  1. customthe solvents removed under reduced pressure
  2. dissolutionThe residue was dissolved in chloroform
  3. washwashed with aqueous sodium bicarbonate
  4. dry with materialwater, dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-1409718e0e304a42b5bf18c039401dbd
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04897385

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