Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzenesulfonyl chloride → 2-Pyrrolidinone, 5-(ethylthio)-1-(phenylsulfonyl)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzenesulfonyl chloride | HCID 7369 | — |
| 반응물 | 5-Ethylthio pyrrolidin-2-one | HCID 19868705 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 2-Pyrrolidinone, 5-(ethylthio)-1-(phenylsulfonyl)- | HCID 3078171 | 65.7% |
반응 단계
To 3.1 g of 5-ethylthio pyrrolidin-2-one in 130 cm3 of tetrahydrofuran there is added at -65° C., 14.2 cm3 of a 1.6M solution of butyllithium in hexane. After 20 minutes, there is added 3.77 g of benzenesulphonyl chloride in 15 cm3 of tetrahydrofuran. After allowing to return to ambient temperature and concentrating to dryness under reduced pressure, 4 g of the expected product is obtained. m.p. 100°-113° C., crystallized from ethanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04897414 |
| 출처 데이터셋 | uspto-grants-1990_01 |
| ORD ID | ord-8d118de13743442f945cc27487e6410c |
| 출처 메모 | uspto-grants-1990_01 |