Trimethylsilyl isocyanate → N-hydroxy-N-{1-[4-(1-phenylethoxy)phenyl]ethyl}urea
반응식
[C:1]1([CH:7]([O:9][C:10]2[CH:15]=[CH:14][C:13]([CH:16]([NH:18][OH:19])[CH3:17])=[CH:12][CH:11]=2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[Si]([N:24]=[C:25]=[O:26])(C)C>O1CCOCC1>[OH:19][N:18]([CH:16]([C:13]1[CH:12]=[CH:11][C:10]([O:9][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH3:8])=[CH:15][CH:14]=1)[CH3:17])[C:25]([NH2:24])=[O:26]참가 물질
4
실험 절차
N-hydroxy-N-(1-(4-(1-phenylethoxy)phenyl)ethyl)urea was prepared using Scheme 2 by refluxing 1-(4-(1-phenylethoxy)phenyl)ethylhydroxylamine (2.22 g 8.64 mmole) for thirty minutes with trimethylsilylisocyanate (1.19 gr, 10.4 mole) in dioxane (30 ml). The reaction mixture was then washed with saturated NH4Cl solution, dried with MgSO4, and evaporated. The residue was washed with ether to give a white solid (1.3 g).