ethyl 3,3-bis(4-fluorophenyl)-2-(1-ethyl-1H-tetrazol-5-yl)-2-propenoate → 3,3-Bis(4-fluorophenyl)-2-(2-ethyl-2H-tetrazol-5-yl)-2-propenol

HRID 330649노트

반응식

HRID 330649 반응식
FC1C=CC(C(C2C=CC(F)=CC=2)=C(C2N(CC)N=NN=2)C(OCC)=O)=CC=1.[F:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]([C:50]2[CH:55]=[CH:54][C:53]([F:56])=[CH:52][CH:51]=2)=[C:37]([C:43]2[N:44]=[N:45][N:46]([CH2:48][CH3:49])[N:47]=2)[C:38](OCC)=[O:39])=[CH:32][CH:31]=1>>[F:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]([C:50]2[CH:51]=[CH:52][C:53]([F:56])=[CH:54][CH:55]=2)=[C:37]([C:43]2[N:44]=[N:45][N:46]([CH2:48][CH3:49])[N:47]=2)[CH2:38][OH:39])=[CH:32][CH:31]=1

참가 물질

3

반응물 2

HCID 14723820ethyl 3,3-bis(4-fluorophenyl)-2-(1-ethyl-1H-tetrazol-5-yl)-2-propenoateHCID 14723821Ethyl 3,3-bis(4-fluorophenyl)-2-(2-ethyl-2H-tetrazol-5-yl)-2-propenoate

생성물 1

HCID 147238243,3-Bis(4-fluorophenyl)-2-(2-ethyl-2H-tetrazol-5-yl)-2-propenol수율 101.1%

실험 절차

The general procedure of Example 46 was repeated, except that the ethyl 3,3-bis(4-fluorophenyl)-2-(1-ethyl-1H-tetrazol-5-yl)-2-propenoate utilized therein was replaced with 1.0 g of ethyl 3,3-bis(4-fluorophenyl)-2-(2-ethyl-2H-tetrazol-5-yl)-2-propenoate and there was thereby produced 0.9 g of the title compound; m.p.=82°-84° C.

출처 및 근거

ORD 기록
ord-6f68d3b661364942854a617f065d9c2d
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04897490

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