Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Naphthalene → Duloxetine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Naphthalene | HCID 931 | — |
| 반응물 | 3-(N-Methylamino)-1-(2-thienyl)-1-propanol, (-)- | HCID 10095047 | — |
| 생성물 | Duloxetine | HCID 60835 | — |
반응 단계
contacting the (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine with an activated naphthalene in a reaction mixture under conditions sufficient to produce (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine (Duloxetine) having the structure of formula (VIII); and (e) recovering the (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine from the reaction mixture.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08877475B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-22aaffe062774d3e82cefa2a869d2bda |
| 출처 메모 | uspto-grants-2014_11 |