Water → 3-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one

HRID 330800노트

반응식

HRID 330800 반응식
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9](=[O:11])[NH:8][C:7]=2[CH:12]=1.Cl.Cl[CH2:17][C:18]1[CH:19]=[C:20]([C:24]2[N:29]=[CH:28][C:27]([O:30][CH2:31][CH2:32][N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)=[CH:26][N:25]=2)[CH:21]=[CH:22][CH:23]=1.C(=O)([O-])[O-].[K+].[K+].O>C(#N)C>[N:33]1([CH2:32][CH2:31][O:30][C:27]2[CH:28]=[N:29][C:24]([C:20]3[CH:19]=[C:18]([CH:23]=[CH:22][CH:21]=3)[CH2:17][N:8]3[C:7]4[CH:12]=[C:3]([C:2]([F:1])([F:13])[F:14])[CH:4]=[CH:5][C:6]=4[S:10][C:9]3=[O:11])=[N:25][CH:26]=2)[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 132273405-(Trifluoromethyl)benzo[d]thiazol-2(3H)-oneHCID 669855014-{2-[2-(3-Chloromethylphenyl)pyrimidin-5-yloxy]ethyl}morpholine hydrochloride

생성물 1

HCID 467007713-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
70 °C

실험 절차

A suspension of 89 mg (0.405 mmol) of 5-trifluoromethyl-3H-benzothiazol-2-one, 150 mg (0.405 mmol) of 4-{2-[2-(3-chloromethylphenyl)pyrimidin-5-yl-oxy]ethyl}morpholine hydrochloride and 286 mg (2.02 mmol) of potassium carbonate in 8 ml of acetonitrile are stirred at 70° C. for 5 days. 30 ml of water are added to the reaction mixture, with a precipitate slowly forming. The precipitate is filtered off with suction, washed with water and dried.

후처리

  1. customslowly forming
  2. filtrationThe precipitate is filtered off with suction
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-d6e890e927a2402ab0aae87c0d87fe88
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877751B2

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