2-Bromo-1-(4-iodophenyl)ethanone → 1-(4-Iodo-phenyl)-2-(4-methyl-imidazol-1-yl)-ethanone
반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)=[O:4].[CH3:12][C:13]1[N:14]=[CH:15][NH:16][CH:17]=1>C(#N)C>[I:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][N:16]2[CH:17]=[C:13]([CH3:12])[N:14]=[CH:15]2)=[CH:6][CH:7]=1참가 물질
4
실험 절차
To 2.50 g (7.69 mmol) 2-bromo-1-(4-iodo-phenyl)-ethanone in 30 mL ACN are added 1.90 g (23.1 mmol) 4-methylimidazole and the mixture is stirred at rt for 48 h. After that time, the solvent is evaporated and the residue is taken up in EtOAc. The mixture is washed with water and brine (2×) and the organic layer is dried over magnesium sulphate. The solvent is evaporated and the residue is recrystallized from diethyl ether to yield the desired product.
후처리
- customAfter that time, the solvent is evaporated
- washThe mixture is washed with water and brine (2×)
- dry with materialthe organic layer is dried over magnesium sulphate
- customThe solvent is evaporated
- customthe residue is recrystallized from diethyl ether
출처 및 근거
- ORD 기록
- ord-44e203a0e8094400a366d51e98363dcc
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08877754B2
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