2-Bromo-1-(4-iodophenyl)ethanone → 1-(4-Iodo-phenyl)-2-(4-methyl-imidazol-1-yl)-ethanone

HRID 330818

반응식

HRID 330818 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)=[O:4].[CH3:12][C:13]1[N:14]=[CH:15][NH:16][CH:17]=1>C(#N)C>[I:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][N:16]2[CH:17]=[C:13]([CH3:12])[N:14]=[CH:15]2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 2565722-Bromo-1-(4-iodophenyl)ethanoneHCID 178418800HCID 178418800, 화합물

생성물 1

HCID 666928261-(4-Iodo-phenyl)-2-(4-methyl-imidazol-1-yl)-ethanone

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To 2.50 g (7.69 mmol) 2-bromo-1-(4-iodo-phenyl)-ethanone in 30 mL ACN are added 1.90 g (23.1 mmol) 4-methylimidazole and the mixture is stirred at rt for 48 h. After that time, the solvent is evaporated and the residue is taken up in EtOAc. The mixture is washed with water and brine (2×) and the organic layer is dried over magnesium sulphate. The solvent is evaporated and the residue is recrystallized from diethyl ether to yield the desired product.

후처리

  1. customAfter that time, the solvent is evaporated
  2. washThe mixture is washed with water and brine (2×)
  3. dry with materialthe organic layer is dried over magnesium sulphate
  4. customThe solvent is evaporated
  5. customthe residue is recrystallized from diethyl ether

출처 및 근거

ORD 기록
ord-44e203a0e8094400a366d51e98363dcc
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877754B2

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