참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | p-Fluoronitrobenzene | HCID 9590 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Thiopheneethanamine | HCID 116521 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | HCID 23104820 | HCID 23104820 | 93.8% |
반응 단계
2 g of 4-fluoronitrobenzene, 2.16 g of 2-thien-2-ylethanamine, and 2.35 g of K2CO3 were added to a solution of 20 ml of N-methyl-pyrrolidinone. The reaction medium was heated at 60° C. for 12 hours and, after cooling to room temperature, was then poured into a water+ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 3.3 g of N-(4-nitrophenyl)-N-(2-thien-2-ylethyl)amine (1) were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07429278B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_09 |
|---|
| ORD ID | ord-3f14fcb3e66f45b29749f1fdcc0ca197 |
|---|
| 출처 메모 | uspto-grants-2008_09 |
|---|
