홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

3-Aminobenzenesulfonic acid → 3-[(4S)-4-amino-5-methoxy-5-oxopentanamido]benzene-1-sulfonic acid

HRID 330870
노트
인쇄 미리보기

반응식

HRID 330870 반응식
CC(OC([NH:8][C@H:9]([C:15]([O:17][CH3:18])=[O:16])[CH2:10][CH2:11][C:12]([OH:14])=O)=O)(C)C.F[P-](F)(F)(F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2N=CC=CC=2N=N1.C1C=NC2N(O)N=NC=2C=1.[NH2:53][C:54]1[CH:55]=[C:56]([S:60]([OH:63])(=[O:62])=[O:61])[CH:57]=[CH:58][CH:59]=1>C(Cl)Cl.FC(F)(F)C(O)=O.C(N(CC)CC)C>[NH2:8][C@H:9]([C:15]([O:17][CH3:18])=[O:16])[CH2:10][CH2:11][C:12]([NH:53][C:54]1[CH:55]=[C:56]([S:60]([OH:63])(=[O:61])=[O:62])[CH:57]=[CH:58][CH:59]=1)=[O:14]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

8

반응물 4

HCID 84743-Aminobenzenesulfonic acidHCID 181649HOAtHCID 7018754(4S)-4-(((tert-butoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

생성물 1

HCID 533792923-[(4S)-4-amino-5-methoxy-5-oxopentanamido]benzene-1-sulfonic acid

시약·촉매·용매 3

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매HCID 8471Triethylamine용매

실험 절차

Boc-Glu-OME, 130 mg (0.5 mmol), 190 mg (0.5 mmol) of 2-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU), 70 mg (0.5 mmol) of 7-aza-1-hydroxybenzotriazole (HOAt) and 87 mg (0.5 mmol) of 3-aminobenzenesulfonic acid were suspended in 2.0 ml of methylene chloride, and 0.5 ml of triethylamine was added to the suspension. The mixture was stirred at room temperature overnight. After the solvent was removed by distillation, the purification step A was applied to give the intermediate. The crude product was dissolved in 4.0 ml of trifluoroacetic acid (TFA) and stirred at room temperature for an hour. After the solvent was removed by distillation, the purification step A was applied to give 7.4 mg of the title compound.

후처리

  1. customAfter the solvent was removed by distillation
  2. customthe purification step A
  3. customto give the intermediate
  4. stirringstirred at room temperature for an hour
  5. customAfter the solvent was removed by distillation
  6. customthe purification step A

출처 및 근거

ORD 기록
ord-db182332e4ce4210a912e5dd18932d79
출처 데이터셋
uspto-grants-2014_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08877739B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트