Thionyl Chloride → 1-(3,3,3-Trifluoropropyl)piperidine-4-carbonyl chloride

반응식

[F:1][C:2]([F:15])([F:14])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([C:11](O)=[O:12])[CH2:7][CH2:6]1.S(Cl)([Cl:18])=O>>[F:1][C:2]([F:15])([F:14])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([C:11]([Cl:18])=[O:12])[CH2:7][CH2:6]1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 59333911HCID 59333911, 화합물

생성물 1

HCID 593339341-(3,3,3-Trifluoropropyl)piperidine-4-carbonyl chloride수율 68%

반응 조건

온도: 80 °C

실험 절차

A suspension of 1-(3,3,3-trifluoropropyl)piperidine-4-carboxylic acid (4.40 g, 20.0 mmol) in thionyl chloride (20 mL) was heat to 80° C. for 15 h. The solution was cooled and concentrated in vacuo to yield a brown foam (3.0 g, 68%).

후처리

temperatureThe solution was cooled
concentrationconcentrated in vacuo

출처 및 근거

ORD 기록: ord-24609cee610845f38a3cfbb85d1dae6e
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08877761B2

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