2,4-Diaminopyrimidine → Imidazo[1,2-A]pyrimidin-7-amine

반응식

N1[CH:2]=[CH:3]N2C(N)=CC=CC=12.[NH2:11][C:12]1[N:17]=[C:16]([NH2:18])[CH:15]=[CH:14][N:13]=1>>[N:11]1[CH:2]=[CH:3][N:13]2[CH:14]=[CH:15][C:16]([NH2:18])=[N:17][C:12]=12

참가 물질

반응물 2

HCID 674312,4-Diaminopyrimidine

HCID 327952Imidazo[1,2-a]pyridin-5-amine

생성물 1

HCID 23000364Imidazo[1,2-A]pyrimidin-7-amine

실험 절차

Intermediate 7 was prepared using methods analogous to those described for Intermediate 6 except 2,4-diaminopyrimidine was the starting material. MS (ESI+): calcd for C6H6N4 m/z 134.06, found 135.1 (M+H)+. 1H NMR (d4-methanol): 8.27 (d, J=7.2, 1H), 7.31 (d, J=1.8, 1H), 7.18 (d, J=1.8, 1H), 6.35 (d, J=7.2, 1H).

출처 및 근거

ORD 기록: ord-6b408e6e19c74c67884e65a046b35323
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08877769B2

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