Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-[3-(4-Chloro-phenoxy)-benzyl]-piperazine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | 4-[3-(4-Chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 67413541 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 1-[3-(4-Chloro-phenoxy)-benzyl]-piperazine hydrochloride | HCID 67413809 | 211.7% |
반응 단계
A solution of 4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester (29.6 g, 73.5 mmol) in 4:1 dioxane:H2O (100 mL) was treated with 4 M HCl in dioxane (60 mL). After 3 h, THF (200 mL) was added and the resulting white precipitate was filtered and dried under vacuum to give 1-[3-(4-chloro-phenoxy)-benzyl]-piperazine hydrochloride (26.4 g, 95%). MS (ESI+): calcd for C17H19ClN2O m/z 302.12, found 303.1 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08877769B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-f795602b1ab64b009dcf27a6892b050c |
| 출처 메모 | uspto-grants-2014_11 |