Methanol → Methyl 4-sulphamoylbenzoate

HRID 331187노트

반응식

HRID 331187 반응식
[NH2:1][S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].S(Cl)(Cl)=O.[CH3:18]O>>[NH2:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C:9]([O:11][CH3:18])=[O:10])=[CH:12][CH:13]=1)(=[O:3])=[O:4]

참가 물질

4

반응물 3

HCID 887MethanolHCID 8739CarzenideHCID 24386Thionyl Chloride

생성물 1

HCID 89847Methyl 4-sulphamoylbenzoate수율 75%

실험 절차

To a suspension of 4-(aminosulfonyl)benzoic acid (500 mg, 2.5 mmol) in MeOH (2 ml) at 0° C. is added thionylchloride (0.2 ml, 7.4 mmol). The reaction mixture is stirred at rt overnight. When TLC confirms the total consumption of the starting acid, the solvent and excess thionyl chloride are removed under reduced pressure to afford 400 mg (75%) of the title compound, which was used in the next step without any further purification. LC/MS: (ES+):215.9, (ES−):214.1.

후처리

  1. customthe total consumption of the starting acid
  2. customthe solvent and excess thionyl chloride are removed under reduced pressure

출처 및 근거

ORD 기록
ord-ca03cd80393e45acabaefc161bf7241a
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877757B2

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