Methanesulfonyl chloride → 2-(2-Fluorophenyl)ethyl methanesulfonate

HRID 331238

반응식

HRID 331238 반응식
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5][OH:6].[CH3:11][S:12](Cl)(=[O:14])=[O:13]>C(N(CC)CC)C.C(Cl)Cl>[CH3:11][S:12]([O:6][CH2:5][CH2:4][C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=1[F:1])(=[O:14])=[O:13]

참가 물질

5

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 27332962-(2-Fluorophenyl)ethan-1-ol

생성물 1

HCID 151245352-(2-Fluorophenyl)ethyl methanesulfonate

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8471Triethylamine용매

실험 절차

To a solution of 2-fluorophenethylalcohol (25.0 g) in triethylamine (37.5 ml) and methylene chloride (250 ml) was added dropwise methanesulfonyl chloride (16.7 ml) under ice-cooling, and the mixture was stirred for 30 min. The reaction mixture was warmed to room temperature, washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated to give 2-(2-fluorophenyl)ethyl methanesulfonate.

후처리

  1. temperaturecooling
  2. washwashed with water and saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c1a992d32f7e4db4abea21507bf12076
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877779B2

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