Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenethyl bromide → 3-(3,5-Difluorophenyl)-6-phenethoxy-2-(pyridin-3-yl)-1H-inden-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenethyl bromide | HCID 7666 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one | HCID 70317432 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-(3,5-Difluorophenyl)-6-phenethoxy-2-(pyridin-3-yl)-1H-inden-1-one | HCID 51001890 | 30% |
반응 단계
To a solution of 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one (0.15 mol, 50 mg) obtained in Step 1 in CH3CN was added K2CO3(1.5 eq). 1-(2-bromoethyl)benzene (1.5 eq) was added dropwise and the resulting mixture was heated to reflux for 3 d. The reaction was cooled to room temperature and diluted with EtOAc. The organic layer was washed with H2O, dried over MgSO4, and concentrated in vacuo to obtain the title compound (30%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08877747B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-86b7d8860c7e4b418708a2ff8c0b2c8a |
| 출처 메모 | uspto-grants-2014_11 |