Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → 3-(3,5-difluorophenyl)-2-(pyridin-3-yl)-6-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)-1H-inden-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| 반응물 | 2-(Oxan-4-yl)ethan-1-ol | HCID 17750944 | — |
| 반응물 | 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one | HCID 70306176 | — |
| 반응물 | 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one | HCID 70317432 | — |
| 생성물 | 3-(3,5-difluorophenyl)-2-(pyridin-3-yl)-6-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)-1H-inden-1-one | HCID 51002045 | 33% |
반응 단계
The procedure of Step 6 of Example 1 was repeated except for using 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one obtained in Step 1 of Example 64 as a starting material instead of 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one, 2-(tetrahydro-2H-pyran-4-yl)ethanol (2.0 eq) instead of 4-(2-hydroxyethyl)morpholine, using 2 equivalents of PPh3 and DIAD, being stirred for 17 h, and being purified by prep. HPLC (20% H2O/CH3CN) to provide the title compound (33%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08877747B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-64036c386eea4da2914d9e04852e0d65 |
| 출처 메모 | uspto-grants-2014_11 |