Piperazine → 6-Chloro-2-(piperazin-1-yl)-1,3-benzothiazole

HRID 33138

반응식

HRID 33138 반응식
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[NH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[S:3][C:4]=2[CH:10]=1

참가 물질

5

반응물 3

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 771762,6-Dichlorobenzothiazole

생성물 1

HCID 27465956-Chloro-2-(piperazin-1-yl)-1,3-benzothiazole

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 10 mmol 2,6-dichlorobenzothiazole, 12.3 mmol of piperazine and 20 mmol of potassium carbonate in 50 ml of acetonitrile was refluxed for 3 hours. The reaction mixture was concentrated and treated with 25 ml of water. Extraction with ethyl acetate, drying over magnesium sulfate, and evaporation of the solvent yielded the title compound as a colorless solid.

후처리

  1. temperaturewas refluxed for 3 hours
  2. concentrationThe reaction mixture was concentrated
  3. additiontreated with 25 ml of water
  4. extractionExtraction with ethyl acetate
  5. dry with materialdrying over magnesium sulfate, and evaporation of the solvent

출처 및 근거

ORD 기록
ord-a26fb20dc43146a1a074d52e7333f8db
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429585B2

연결된 노트

불러오는 중…